Radiotherapy-associated intra-abdominal angiosarcoma after prostatic adenocarcinoma: Case reports.

Angiosarcoma is a rare soft tissue neoplasm, which accounts for <1% of all soft tissue tumours. It has been previously reported that the incidence rate of angiosarcomas increases following radiotherapy. The present study reports two cases of intra-abdominal angiosarcoma associated with previous radiotherapy treatment. To the best of our knowledge, these associations have not been previously described in English literature. The patients aged 71 and 83 years were admitted to the center for abdominal pain and diarrhea. Each patient had previously had treatment with radiotherapy for prostate adenocarcinoma. During their hospitalization, biopsies were obtained and the diagnosis of angiosarcoma was reached. In each patient the tumors had irregular proliferating vascular channels, lined by atypical endothelial cells, which varied from elongated and spindle-shaped to large and plump. Immunocytochemistry revealed that the tumor cells were positive for the cytoplasmic endothelial markers cluster of differentiation (CD)31 and CD34. The recognition of these associations is important and their occurrence in this rare type of neoplasm should not mislead the pathologist and cause a misdiagnosis of the sarcoma.

Carcinoma adrenocortical no funcionante con mielolipoma. Una rara asociación / Non-functioning adrenocortical carcinoma associated with myelolipoma. A case report

El carcinoma adrenocortical es un tumor infrecuente con una incidencia de 1 por millón de habitantes por año. El 80% aproximadamente de estos carcinomas son funcionantes, representando los no funcionantes solo un 20% de los carcinomas comunicados en las mayores series de la literatura. Se trató de paciente masculino de 55 años de edad con tumor adrenal derecho de 75×62mm. La pieza quirúrgica fue procesada para histología e inmunohistoquímica convencional. El tumor estaba constituido por células redondeadas, eosinofílicas, dispuestas en sabanas y en trabéculas. Se observaron de 3–5 figuras de mitosis en 50 campos de gran aumento y se identificó invasión vascular y sinusoidal. Se evidenció la presencia de mielolipoma entremezclado con el tumor y en la periferia del mismo. Solo 5 casos de carcinoma adrenocortical y concomitante mielolipoma han sido descritos en la literatura médica. En nuestro conocimiento mielolipoma asociado con carcinoma adrenocortical no funcionante no ha sido descrito previamente(AU)

Adrenocortical carcinoma is a rare tumour, with an annual incidence of only one case per million. Functioning tumours account for about 80% of all adrenocortical carcinomas, whereas non-functioning tumours are even rarer, accounting for only 20% of adrenal carcinomas in the largest reported series. We present a case of a 75×62mm right adrenal tumour occurring in a 55 year old male. Routine histological and immunohistochemical examinations were carried out on the surgical specimen. The tumour cells were mostly round, eosinophilic cells arranged in a sheet-like or trabecular pattern separated by thick fibrous bands. 3 to 5 mitoses were seen in 50 high-power fields; vascular and sinusoidal invasion was observed. A myelolipoma was found intermixed with the tumour at its periphery. To date, only five cases of adrenocortical carcinoma with concomitant myelolipoma have been published and to the best of our knowledge, this is the first report of myelolipoma associated with non-functioning adrenocortical carcinoma(AU)

Extrapleural solitary fibrous tumour with haemangiopericytic pattern of the breast. An uncommon neoplasm

El tumor fibroso solitario extrapleural es un tumormesenquimal de probable origen fibroblástico. La mama esun sitio infrecuente para un tumor fibroso solitario extrapleural.Este trabajo documenta las características clínicas,histológicas e inmunohistoquímicas en un caso de tumorfibroso solitario de la mama, y discute el probable origen deesta neoplasia. Se trata de una mujer de 43 años que consultópor una masa no dolorosa en la glándula mamariaizquierda de diez meses de evolución. La mamografíaizquierda mostró una lesión nodular de 10 cm densa, biendefinida. Se realizó mastectomía sin vaciamiento axilar.Tras cirugía, la totalidad del tumor fue enviado para estudiohistopatológico. El tumor estaba formado por una proliferaciónde células fusiformes distribuidas irregularmente en unestroma con áreas de variable colagenización y vasos sanguíneosde tamaño mediano y paredes delgadas en unpatrón de crecimiento hemangiopericítico. El estudio inmunohistoquímicodemostró fuerte positividad para CD34 yCD99. Nuestro caso representa un típico tumor fibroso solitarioextrapleural con patrón hemangiopericítico. Loshallazgos descritos apoyan al estroma perilobular o interlobularcomo probable origen de estas lesiones(AU)

Extrapleural solitary fibrous tumour is a mesenchymaltumour, probably of fibroblastic type, occurring only rarelyin the breast. A case of solitary fibrous tumour of the breastis presented and the possible origin of this neoplasm is discussed.A 43-year-old woman presented with a ten monthhistory of a painless, enlarging mass in the left breast, whichwas seen on mammography to be a 10 cm, dense, nodular,well delimited lesion,. A left mastectomy without axillarydissection was performed. Histologically, the tumour wascomposed of a proliferation of haphazardly distributed fusocellularelements and varying degrees of stromal collagenization.Medium-sized thin-walled blood vessels in a haemangiopericyticgrowth pattern were observed. The immunohistochemicalstudy showed strong CD34 and CD99positivity. This case represents a typical extrapleural solitaryfibrous tumour with a haemangiopericytoma pattern. Ourfindings would indicate that the most probable origin of thislesion was the perilobular or interlobular stroma(AU)